Sodium Butyrate

Sodium Butyrate Gut Health Supplement

Sodium Butyrate Gut Health Supplement

Sodium Butyrate supports the formation of friendly bacteria that enhances probiotics to help promote digestive health.

It is unlikely that you get enough butyrate from your food sources to be physiologically beneficial, making butyrate supplementation a prudent habit.

In this sodium butyrate supplement guide we’re going to explain:

  1. Sodium Butyrate as a Short Chain Fatty Acid
  2. The science behind Histone Deacyetylase
  3. Gene Expression
  4. Sodium Butyrate and Cell Proliferation
  5. Sodium butyrate and adipose tissue
  6. The Best Sodium Butyrate Supplement is actually Tributyrate
  7. Where to buy Sodium Butyrate’s Better Alternative

Sodium Butyrate

Sodium Butyrate as a Short Chain Fatty Acid

Fatty acids are organic compounds that contain carbon, hydrogen and oxygen atoms. They are classified into two categories: saturated fatty acids (no double bonds) or unsaturated fatty acids (at least one double bond).

Sodium butyrate is a short-chain fatty acid sodium salt of butyric acid, which is part of the group of compounds known as volatile fatty acids (VFA’s). VFAs are named that because they evaporate easily and have a distinctive, foul smell.

Sodium butyrate is one of the most common short-chain fatty acids found in the colon and it boosts cell proliferation, stimulates differentiation and helps maintain the integrity of intestinal cells.

The Science behind Histone Deacetylase

Histones are proteins around which DNA strands are wound.

They act as spools to compact or expand the DNA, preventing it from unravelling so as to properly fit inside a cell.

This process can be likened to closing up an umbrella after using it: you pull on all four ‘spokes’ until fabric clings together into a ball.

The DNA is wrapped around histones in much the same way, and any modifications to histones will result in changes to DNA structure.

Histone deacetylase inhibitor

Histone deacetylase inhibitor involves the process of adding acetyl groups to histones , which make them more positive.

The addition of acetyl groups results in changes in DNA structure (unwinding) and the expression of associated genes .

These genes are responsible for improving cellular health, leading to improved muscle growth among many other benefits. Moreover, Histone deacetylase inhibitor in sodium butyrate supplement provides multiple health benefits in the intestine.

Gene Expression

Different types of cells use different gene expression methods. For sodium butyrate, gene expression depends on which histone deacetylase it interacts with.

This interaction determines whether sodium butyrate acts as a metabolic intermediate or inhibitor of T cell activation . It can also either stimulate or inhibit human B cell proliferation, depending on sodium butyrate concentration.

Sodium Butyrate and Cell Proliferation

Sodium butyrate supplementation has been shown to reduce mammary tumor formation and tumor size in rodents.

It is believed that sodium butyrate works by modulating multiple cell signaling pathways .

Butyric acid in stem cell research

Another sodium butyrate benefit is that it induces bone marrow and umbilical cord blood stem cell proliferation, helping to expand the pool of hematopoietic stem cells.

These findings were noted in stem cell research showing sodium butyrate is a potential hematopoietic stem cell self-renewal agent .

This helps with tissue repair, wound healing and overall recovery from injury or illness.

Sodium butyrate and adipose tissue

In sodium butyrate supplementation, sodium butyrate components that are absorbed into the blood stream can help regulate adipose tissue .

The sodium form of sodium butyrate can modulate adipocyte proliferation and differentiation.

This sodium butyrate benefit occurs via sodium-butyrate regulated expression of Wnt proteins , which is involved in adipocyte differentiation.

Sodium Butyrate and Bone Loss Prevention

Osteoporosis is a skeletal disorder characterized by low bone mass and deterioration of bone tissue, which leads to increased risk for fractures .

Bone loss sodium butyrate treatment works best when sodium butyrate and sodium chloride (salt) are combined .

The sodium salt of sodium butyrate is sodium butyrate.

Sodium chloride supplementation in sodium butyrate treatment helps prevent osteoporosis and treat bone loss in postmenopausal women .

This was the conclusion in a sodium butyrate study, where it found that sodium butyrate and sodium chloride combined improved bone density.

Sodium butyrate sodium chloride combined can also increase bone density in rodents with osteoporosis .

The Best Sodium Butyrate Supplement is actually Tributyrin

We use sodium butyrate (sodium salt of butyric acid) products because sodium butyrate has shown to be effective for improving gut health and promoting healthy bacteria growth, which makes it an essential component of our Gut Health Formula .

However, sodium butyrate supplements come with a catch.

Sodium butyrate supplements are poorly absorbed into the body (only about 6% of orally ingested sodium butyrate reaches the bloodstream) which means you get less for your money than if you used tributyrin, the active ingredient in Viscera-3 gut health supplement.

Tributyrin supplements are designed to be absorbed efficiently so you get more sodium butyrate in the blood and in the cells.

Where Can You Buy Viscera-3?

Viscera-3 gut health supplement has been our best selling sodium tributyrate product for a very long time, and it continues to be extremely popular even today.

You can buy Viscera-3 sodium butyrate from our store now, or keep checking back to see if we have any special offers on sodium butyrate supplements next time you visit the site!

YouTube video

Celebrating Retirement and 73 Pounds Gone!

I can’t remember how long it was that I avoided my bathroom scale.  It taunted me every morning, but I subscribed to the idea that what I didn’t know, wouldn’t hurt me.   One morning, when I was feeling particularly brave, I finally stepped on.    I should have been mortified when the dial said 208 lbs. but instead, I was relieved.   From the way I felt physically, I thought the number would be higher.  My blood pressure was high, my cholesterol was borderline and chronic knee pain along with the burden of carrying all that weight prevented me from enjoying activities that involved any exertion.   And the frustration of years of yo-yo dieting stopped me from embarking on any diet program.  I told myself that l would try to eat healthily but was not going to put myself through another starvation diet.  Being heavy was just part of who I was, I told myself.  Denial.

The kicker for me was came when, during a family vacation, I was physically unable to join everyone in a hike.  I remember overhearing a family member say, “What will we do with Judy?”  Staying behind and knowing that several family members who were older than myself were able to enjoy a long walk was humiliating and embarrassing.  It was a wake-up call. 

Fortunately, the event coincided with hearing about the SANE Ignite program from a friend.  I was skeptical at first because all programs promise that you can eat and not be hungry and still lose weight.  I had been on enough diets and found that not to be true.  Still, what drew me to SANE was the idea of aspiring to reach a “setpoint” so that when I did reach my goal, I wouldn’t instantly gain the weight back and more when I began maintenance eating.   It was worth a shot, I thought.  And so, my journey began.

That was 73 pounds ago and I can honestly say that I did not experience one day of unsatisfied hunger.  Before SANE, I would have regular feasts on chips, but I was amazed at how quickly my chips and other cravings disappeared.  I learned to substitute empty calorie foods with healthy SANE foods; now my junk food cravings are gone.

The great thing about the program is that it accommodates all types of food preferences and restrictions within the framework of eating vegetables, protein and fat.  As a pescatarian, I found it easy to make it work; the only adjustment I made was the elimination of unhealthy food.

My day begins with an egg white bruschetta omelet that I bake in the oven.  It makes 4 generous servings, so I only need to bake one every 4 days.  For lunch, I have some sort of canned fish along with a green smoothie.  I have always enjoyed eating a big dinner, so I have a big bowl of green soup, a huge portion of fish (usually salmon, trout or cod) and a large salad.  A snack might include one of the yummy SANE sweets like Chocolate Chunk Bars or just a bowl of cherries.

I think that the key to my success was ensuring that I took advantage of everything the SANE Ignite program had to offer.  I logged my food every day, took a few minutes to do the lessons and utilized the support available in my program and from my coach.  It’s vital to stay connected to the SANE community and make sure that you are reaching out when you are in need and that you are sharing your successes with others.  Another amazing part of the program is monthly live group coaching calls where you can ask Jonathon questions.  They are recorded so if you miss one, you can watch them anytime.  I often pull one up and listen to it while I am doing housework. 

Now, not only have my blood pressure and cholesterol levels normalized, but I am more physically active than I have been for 10 years.  I feel amazing.  And I am the one who organizes our family hikes!

This isn’t the first time that I have reached my goal weight, but it will undoubtedly be my last.   I can say this with confidence because I just love the way that I eat and am happy to continue that way for life.  Thank you, SANE Solution!

SANESolution Vitaae

Vitaae™ Reviews: Does it Work and is it Safe?

Vitaae Reviews: Clearing the Fog

 

After years of development in the lab and thousands of 5-star reviews from verified users of this product, we can confidently say that Vitaae™does work and is safe for most people when taken as directed. Just look at some of these glowing Vitaae™!

sane solutions vitaae reviews

Vitaae™ Reviews: No More Brain Fog!

 

★★★★★

“I just love this! I have been taking it for 2 months now, and my brain fog is nearly gone. I have more energy. I exercise more, and I feel very vibrant all over, not just mentally. And I am down 7 pounds so that is a bonus.”

-Terry L

★★★★★

“My reaction was dramatic. Within 48 hours the tightness in my head went away and the brain fog lifted. I could think again!”

-Dena A

★★★★★

SANE Vitaae™ Overview

SANE Vitaae™ is a clinically proven brain-health and anti-aging breakthrough that can help anyone at any stage of life think clearer, feel better, and reverse chronic psychological and metabolic issues.

Vitaae™ helps you fix neurological inflammation and reverse the signs of aging with the four proven super nutrients discussed later in this article.

Vitaae™ contains all-natural ingredients that may help you:

  • Fix leaky brain
  • Improve mental clarity
  • Boost metabolism
  • Experience rapid unexpected weight loss as a side effect of fixing neurological inflammation
  • Reclaim your youthful energy
  • Enjoy all day cellular energy
  • Reverse memory loss
  • Reduce the risk of obesity, diabetes, and heart disease

 

You might be thinking at this point: How can one natural supplement provide all these varied and amazing health benefits?

Read on.

What Can I Expect From Taking SANE Vitaae™?

Vitaae™ contains 4 bioavailable natural ingredients that synergistically work together to fix leaky brain and reduce or eliminate brain inflammation, thereby improving almost all areas of your health.

We’ll discuss the science behind these nutrients in a moment, but first…here’s what you can expect from taking Vitaae™ regularly:

Vitaae™ will enable you to experience a whole new world where you will reverse the neurological aging and inflammation that leads to low-energy, anxiety, depression, mood swings, brain fog, trouble focusing, a slowing metabolism, memory loss and so many other symptoms of what we often accept as “just a part aging”. 

This is because this natural supplement contains patented quatrefolic proven to be 7 times more powerful1 than conventional folate.

 

Improved Brain Function, Better Health!

Your brain function and mood will continue to noticeably improve because of patented Cognizin Citicoline that’s proven to support brain cellular synthesis, brain energy, and focus. Specifically up to a 90% decrease in focus errors2 for middle age women in clinical studies… as well as a 13.6% increase in brain energy utilization,3 and a 26% increase in membrane turnover,4 which is literally the reversal of aging of your brain.

You will enjoy all day energy thanks to patented MicroActive CoQ10, with 24 hour timed release and 3 times better absorption than regular CoQ10.5

You will be delighted by the improved mental clarity, deeper concentration,6 better moods, and improved weight loss thanks to the synergistic power of therapeutic doses of L-carnitine combined with l-Acetyl-carnitine.

Seriously, get ready to reclaim your youthful energy and sharp mind from the inside out with new, patented, and clinically proven ingredients that have never been put together into a single, easy to take formula before.

But don’t take our word for it. Check out a few more Vitaae™ Reviews from verified users of this brain-boosting product.

is vitaae fda approved

More Customer Reviews

★★★★★

“Vitaae™ is my hero! Since I started taking Vitaae™ daily, back in 2018, my life has changed! I have energy to do what I want! My brain power has increased so much I can once again enjoy people, places and things. I’m actively enjoying life! My motto these days is “BE HAPPY!” and thanks to Vitaae™, I am!”

-Jean S

★★★★★

For me SANE Vitaae™ makes me feel less hungry (a bonus!) and also gives me better mental clarity. I used to have trouble finding words or recalling info when talking. Vitaae™ seems to help with this significantly. This is huge as an Executive, to speak with authority.

-Jennifer L

★★★★★

This has literally changed the lives of everyone in my family. For me, I feel like those rare “moments of clarity” I used to have are just the way my mind works now. My husband says that he needs less time and coffee to “get going” in the morning and that things are just coming to him now.

-Katey W

★★★★★

After taking sane for three days I realized I finally had something that works! I no longer walk into a room and wonder why I’m there. I am 67 and I have never felt such mental clarity in a very long time. Much more energy, much more peace!

-Peggy P

★★★★★

 

Natural Ingredients in Vitaae™

Magnafolate C🇷

Magnafolate C is a patented, highly absorbable form of the B-vitamin folate.

Folate is commonly known as a prenatal vitamin. In fact, to prepare for pregnancy, women are advised to take 400 to 1,000 mcg of folic acid a day , as it is crucial to reduce the risk of birth defects of the brain and spine of the unborn child.7 (Folic acid is the synthetic form of folate.)

Folate is important for red and white blood cell growth and formation. It also produces DNA and RNA, helps metabolize amino acids, and performs many other important health functions.

Research shows that folate is also essential for brain health.

According to King’s College neurologists:

” It is becoming clear that folic acid affects mood and cognitive function, especially in older people… Within the wide spectrum of depressive disorders, a subgroup has been identified in which folate… [is] involved. With respect to dementia, there is evidence that folate deficiency may contribute to the cognitive impairment of the ageing brain… increasing the risk of Alzheimer’s disease and vascular dementia.”8

vitaae for throat phlegm

Why it’s Difficult to Get Enough Folate

As you can see, proper brain function depends upon getting enough folate into your body. However, folic acid and folate from ALL conventional sources must be converted into 5-methylfolate (MTHF) before your body can use it. The enzyme MTHFR is required to do this. But scientists recently discovered that many of us have polymorphic forms of this enzyme and do not produce adequate or effective MTHFR.

And even if you don’t suffer from this common genetic issue, folate in food is very unstable and is rapidly lost during processing. For example, leafy vegetables stored at room temperature may lose up to 70% of their folate activity within three days and cooking those greens causes up to 95% to be lost.

Even worse, your body can’t store folate, so it must be consumed in optimal amounts every single day to avoid deficiency. 

So with all these issues, how can you get enough folate?

Two words: SANE Vitaae™

You see, SANE Vitaae™ contains the specific patented form of folate called quatrefolic (Magnafolate C), clinically proven to be up to 7 times more bioavailable9 than the folate supplements found on store shelves. This patented form of folate is instantly converted by EVERY body — bypassing the genetic discussed earlier — to the active form of 5-MTHF.

Cognizin Citicoline

Citicoline is a natural chemical in the body that supports brain health. In fact, citicoline is the main ingredient in many brain health supplements.

It is the precursor to choline, an essential nutrient found in eggs and other foods. Choline is great for the brain, which is why eggs are considered a “brain food”. (Citicoline actually converts to choline in the brain, so it helps increase the amount of this brain-boosting nutrient.) It helps support your brain’s energy producing centers and plays a role in neurotransmitter function.

Citicoline has long been used for brain health.

In the 1970s, for instance, doctors in Japan first used citicoline to treat stroke victims. These doctors found if they gave their patients citicoline within 24 hours of having a stroke, they were able to recover completely.

Citicoline has been the subject of many clinical research studies that suggest that it may provide potent brain health benefits.

 A body of research shows that citicoline may be an effective treatment for memory disorders.10

Additionally, a clinical research study has shown that Cognizin©, the superior branded form of citicoline found in Vitaae™, increased brain energy by 14 percent and sped up the formation of brain membranes by a whopping 26 percent in healthy adults!11

This certainly indicates that Cognizin© citicoline improves overall brain function!

sanesolution reviews

L-Carnitine Tartrate and Acetyl-L-Carnitine

L-Carnitine tartrate and Acetyl-L-Carnitine are compounds similar to an amino acid. Carnitine has been getting a lot of attention recently for good reason… it’s the only molecule in our cells with the ability to move fatty acids into the mitochondria where it’s used for energy. Because of this, a low carnitine level can have serious consequences, such as heart arrhythmia and muscle degradation.

Supplementing with the right type and dose of L-carnitine has also been shown in recent studies to help you burn more fat. In one study, overweight participants received a regular diet, either with or without the addition of L-carnitine. After 10 days, L-carnitine was found to significantly increase the breakdown of fat.12

Now while L-Carnitine works to bring more energy to your cells, it also has and equally important biological helper called Acetyl-L-Carnitine which is a brain cholinergic which means that it mimics the neurotransmitter acetylcholine which is incredibly important in improving memory and brain health.

Also, it stands out amongst other cholinergic because it is a powerful antioxidant and can pass the blood brain barrier where it also supports healthy blood flow to the brain. This transformative amino acid acetyl-L-carnitine a goes straight into your brain, where it helps improve memory, mood, cognition and learning.13

Coenzyme Q-10 (CoQ10)

Coenzyme Q-10 (CoQ10) is a vitamin-like substance produced naturally by the body.

It lives within the mitochondria of every cell. The mitochondria are the energy-producing part of the cells, and CoQ10 sparks energy within these cells. It especially ignites energy within heart and brain cells.

This means CoQ10 can support heart and brain health. Studies show that this nutrient not only helps fix brain-related issues,14 but it may also help reduce risk of cardiovascular disease.15

In order to reap all these brain health benefits, however, it’s important that you choose an absorbable and bioavailable version of COQ. The new patented Microactive™ CoQ10 in Vitaae™ is the only form available that offers 100% “assured bioavailability” to everyone.

sane vitaae reviews

Still More Customer Reviews

★★★★★

“I was a nurse for 30 years. So I put a lot of attention to what I put into my body, and I am always hesitant about supplements. But I have to say after doing my own in-depth research on the formulation, the ingredients, especially the well studied patented versions, are really top notch.”

Helen K.

★★★★★

At 62 Vitaae™ is the one thing that has really helped me to have a better attitude, a better outlook and a sharper mind. I feel like I have more energy and have lost 5 pounds already, as I am definitely more active. I have been so disappointed with the mental focus products out there because none have worked until trying Vitaae™.”

-Camilla A.

★★★★★

I’ve not been taking the supplements very long but I’ve already noticed that I can “see” things better… like picking out all the objects in a game type of thing. And I seem to be able to think easier. I’m 67 and had been noticing a decline in my thinking abilities! I’m very pleased

-Cindy K

★★★★★

Other Natural Ingredients in SANE Vitaae™

In addition to the aforementioned ingredients, Vitaae™ contains:

 

Gymnema Sylvestre Leaf Extract

A natural woody vine native to China, Asia, Africa and other regions, Gymnema Sylvestre Leaf Extract may help control blood glucose levels which in turn can prevent weight gain or help you lose weight.16

Gymnema Sylvestre Leaf Extract is part of the VitaalMind™ proprietary blend.

Omega-3 Fatty Acids

Vitaae™ also contains omega-3s in the form of refined fish oil. (This is also part of the  VitaalMind™ proprietary blend.)

Research suggests that omega-3 fatty acids may help fight mental disorders, such as anxiety and depression.17, 18 It can also help reduce inflammation, which is may also prevent memory loss and support brain health.19

Vitamin D

Vitamin D is essential for the proper absorption of calcium. Among many other health benefits, vitamin D has anti-inflammatory properties that may defend against several conditions and diseases.

Is SANE Vitaae™ Safe?

Vitaae™ is guaranteed safe with multiple levels of quality assurance. It is made from the highest quality ingredients in a N.S.F. and FDA G.M.P. certified manufacturing facility based in the USA.

There are no reported side effects. However, you may experience rapid unexpected weight loss as a side effect of fixing neurological inflammation.16 So, if you don’t have at least 10 lbs to lose, please consult your doctor before using Vitaae™.

How Many Capsules Should I Take Each Day?

We recommend that you take 3 capsules once or twice a day with a meal.

vitaae

Is There a Money-Back Guarantee?

Yes, there is!

When you order the SANE Vitaae™ supplement, you’re fully covered by our one year, 100% Money-Back Guarantee.

We know you’ll love Vitaae™, but if you are not satisfied for any reason, just call our certified wellness experts and they’ll immediately start processing your refund. No hassle and no questions asked.

References

1- Willems FF, et al. Br J Pharmacol. 2004 Mar;141(5):825-30. [PMID: 14769778]

2- Silveri MM et al. Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. NMR Biomed. 2008;21(10):1066-75

3- McGlade E. et al., Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women. Food and Nutrition Sciences. 2012;3:769-773.

4- Yurelun-Todd D et al. The Effects of Citicoline Supplementation on Motor Speed and Attention in Adolescent Males. J0urnal of Attention Disorders. 2015; 1557-1246

5- Madhavi D, Kagan D. Integrative Med. 2010 Feb/Mar;9(1):20-4.

6- Kobayashi, S, et al. Acetyl-L-carnitine improves aged brain function. Geriatr Gerontol Int. 2010 Jul;10 Suppl 1:S99-106.

7- American Pregnancy Association. Folate and Folic Acid in Pregnancy. Accessed Jul 26, 2021. https://americanpregnancy.org/getting-pregnant/infertility/folate-vs-folic-acid/

8- Reynolds EH. Folic acid, ageing, depression, and dementia. BMJ. 2002;324(7352):1512-1515. doi:10.1136/bmj.324.7352.1512

9- Willems FF, et al. Br J Pharmacol. 2004 Mar;141(5):825-30. [PMID: 14769778]

10- Dávalos A, Castillo J, Alvarez-Sabín J, Secades JJ, Mercadal J, López S, Cobo E, Warach S, Sherman D, Clark WM, Lozano R. Oral citicoline in acute ischemic stroke: an individual patient data pooling analysis of clinical trials. Stroke. 2002 Dec;33(12):2850-7. doi: 10.1161/01.str.0000038691.03334.71. PMID: 12468781.

11- Silveri MM, Dikan J, Ross AJ, Jensen JE, Kamiya T, Kawada Y, Renshaw PF, Yurgelun-Todd DA. Cognizin® Citicoline Increases Brain Energy (ATP) by 14% and Speeds up Formation of Brain Membranes by 26% in Healthy Adults. Society for Neuroscience, San Diego California.

12- Wutzke KD, Lorenz H. The effect of l-carnitine on fat oxidation, protein turnover, and body composition in slightly overweight subjects. Metabolism. 2004 Aug;53(8):1002-6. doi: 10.1016/j.metabol.2004.03.007. PMID: 15281008.

13- Kobayashi, S, et al. Acetyl-L-carnitine improves aged brain function. Geriatr Gerontol Int. 2010 Jul;10 Suppl 1:S99-106.

14- Monsef A, Shahidi S, Komaki A. Influence of Chronic Coenzyme Q10 Supplementation on Cognitive Function, Learning, and Memory in Healthy and Diabetic Middle-Aged Rats. Neuropsychobiology. 2019;77(2):92-100. doi: 10.1159/000495520. Epub 2018 Dec 21. PMID: 30580330.

15- Ayers J, Cook J, Koenig RA, Sisson EM, Dixon DL. Recent Developments in the Role of Coenzyme Q10 for Coronary Heart Disease: a Systematic Review. Curr Atheroscler Rep. 2018 May 16;20(6):29. doi: 10.1007/s11883-018-0730-1. PMID: 29766349.

16- Shanmugasundaram ER, Rajeswari G, Baskaran K, Rajesh Kumar BR, Radha Shanmugasundaram K, Kizar Ahmath B. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol. 1990 Oct;30(3):281-94. doi: 10.1016/0378-8741(90)90107-5. PMID: 2259216.

17- Grosso G, Galvano F, Marventano S, et al. Omega-3 fatty acids and depression: scientific evidence and biological mechanisms. Oxid Med Cell Longev. 2014;2014:313570. doi:10.1155/2014/313570

18- Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Glaser R. Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial. Brain Behav Immun. 2011 Nov;25(8):1725-34. doi: 10.1016/j.bbi.2011.07.229. Epub 2011 Jul 19. PMID: 21784145; PMCID: PMC3191260.

19- Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Glaser R. Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial. Brain Behav Immun. 2011 Nov;25(8):1725-34. doi: 10.1016/j.bbi.2011.07.229. Epub 2011 Jul 19. PMID: 21784145; PMCID: PMC3191260.

20- Martin Valdearcos, John D. Douglass, Megan M. Robblee, Mauricio D. Dorfman, Daniel R. Stifler, Mariko L. Bennett, Irene Gerritse, Rachael Fasnacht, Ben A. Barres, Joshua P. Thaler, Suneil K. Koliwad. Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility. Cell Metabolism, 2017; 26 (1): 185 DOI: 10.1016/j.cmet.2017.05.015.

viscera-3 reviews

SANE Viscera-3™ Reviews: Does this Postbiotic Supplement Work?

SANE Viscera-3 Reviews

 

Viscera-3™ users are raving about this groundbreaking postbiotics supplement. They’ve even taken the time to write glowing Viscera-3™ reviews. 

Here’s a Typical Viscera-3 Review:

 

“After ten years of dealing with stomach issues, and trying several products,  I was hopeful that Viscera-3TM would help with my painful gas and bloating.  My mother, who suffers from ulcerative colitis, complained constantly of her stomach being swollen and bloated. I decided that if it worked for me, it could be an option for her.

 

I was happily surprised that after only 3 days, I experienced relief!  My stomach is now flat again and I no longer experience any issues with gas and bloating.

 

 For anyone thinking about trying Viscera-3TM, try it and give it a chance to work; even though I found relief in 3 days, that may not be typical so give it time. Thank you SANE for making a product at a reasonable price that actually works!”

 

-Tanya S

How Does Viscera-3 Work?

SANE Viscera-3™ works by transporting butyrate to the lower colon. Butyrate, a short-chain fatty acid,  is one of the most studied postbiotic metabolites and one that may provide the most gut health benefits. Research also indicates that butyrate may supply a host of other health benefits, including a slimmer gut!

 

Viscera-3™ also contains 4 other natural nutrients clinically shown to support gut and overall health. 

 

What is a Postbiotic?

 

Postbiotics are the “waste products” of intestinal fermentation of resistant starches, aka fiber, in the lower colon. 

 

You are probably much more familiar with probiotics and prebiotics than you are with postbiotics. In fact, it’s likely that “postbiotics” is a new term for you. 

 

However, research reveals that postbiotics may be responsible for most of the health benefits commonly attributed to fiber intake.

 

Here’s a brief review of the relationship among probiotics, prebiotics and postbiotics. 

 

Viscera-3 Reviews

 

Probiotics

 

Probiotics are beneficial bacteria and other microorganisms living in your digestive tract. These bacteria break down foods in your gut, extract nutrients from these foods, and perform many other tasks. 

Beneficial bacteria are crucial to maintaining a proper balance of good and bad bacteria. If you don’t have enough good bacteria in your gut, bad bacteria would overrun the system and lead to health issues. 

You can increase good bacteria in your gut by taking probiotic supplements or by eating probiotic foods, such as sauerkraut or yogurt.

 

Viscera-3 Reviews

Prebiotics

 

Prebiotics are fibers (resistant starches) that beneficial bacteria need to survive and thrive. 

The preferred way to feed your good gut bacteria is to eat plenty of fiber foods, such as non-starchy vegetables and whole grains. You can also take fiber supplements, which are often found in both powder and pill forms.

The problem with eating a large amount of fiber, however, is that it can create excessive gas. This is likely if you suddenly increase your fiber intake. The gas comes from bacterial fermentation of fiber in your lower colon. 

And this leads us to a discussion of postbiotics.

 

Postbiotics

Postbiotics are the waste products of bacterial fermentation of fiber. In other words, when bacteria ferment (eat) fiber, they “poop” out postbiotic metabolites.

 

These postbiotics were once considered true waste products that offered no value to human health. In the past few years, however, research suggests that postbiotics are essential to health and wellness. More than 22,000 postbiotic metabolites including butyrate have been identified in scientific literature1. 

 

As previously mentioned, studies suggest that butyrate may provide a wide variety of mental, emotional, and physical health benefits. And thousands of Viscera-3™ users attest to the health benefits of butyrate. 

 

Viscera-3™ Reviews

 

Here are a few 5-star Viscera-3 reviews:

 

★★★★★

 

“Thank you guys for creating this! It really has been a godsend as someone who has always had belly issues. Gas, bloating, diarrhea…even the worst…having to change my underwear in the middle of the day – you name it, I have dealt with it. 

 

I still get gas from time to time, but I really don’t have to be as selective with what I eat anymore and it’s allowed me to add more greens to my diet which has helped me with other health issues. I really can say I do feel lighter and less constricted since I no longer struggle with constipation.“

 

-Robert W

 

★★★★★

 

“I know it’s a sensitive thing to talk about this, but after just three days, I think, of taking Viscera-3 I saw a pretty big difference in the toilet. I won’t go into too much detail but it’s safe to say it’s much more solid and it seems to be very regular and at the same time each morning. 

 

Before taking Viscera-3 it was definitely not as solid and I would have multiple trips to the bathroom in the day.”

 

-Timothy S

 

★★★★★

 

“At 64 I have suffered from digestion issues for years, especially if I ate too many greens, like spinach or even beans. I would get really painful bloating and constipation. It really makes sense when you talk about how things actually ferment in your gut. It’s not fun. 

 

I have tried everything, and nothing has done what Viscera-3™ has done. I can finally get my greens in without worry about the pain and gas. I have finally talked my wife into trying it and I am more than happy to report her gas is also much reduced. It has made our house a more pleasant place.”

 

-John K

 

★★★★★

 

“I never thought I would fall in love with a supplement this quickly but boy Viscera-3™ is the real deal and I swear by it every day. 

 

I used to have a pretty loud belly and have been known for bad painful gas. Not pleasant! Viscera-3™ has made such a big difference. Far less bloating and gas has reduced quite a bit. Hard to explain but I feel lighter.”

 

-Abigale

 

★★★★★

 

“Thank you thank you thank you! I finally know what it’s like to have a healthy gut. Less bloating and gas, more regular and totally solid poops. Such a funny thing to get excited about but it’s true. Really a remarkable product that has given me so much of my life back.”

 

-Stacy W

 

Health Benefits of Butyrate in Viscera-3

 

Here are just a few of the numerous health benefits of the butyrate in Viscera-3™. 

 

Improves Gut Health

 

Multiple research studies suggest that butyrate may improve gut health. A large number of people routinely suffer from digestive problems or digestive diseases.

 

Consider this: the National Institute of Health reports that up to 70 million people in the US suffer from at least one digestive disease.2 Some of the most common digestive diseases include chronic constipation, inflammatory bowel disease, irritable bowel syndrome (IBS), and diverticular disease.

 

According to a 2013 study, butyrate can reduce the hypersensitivity of intestinal receptors, resulting in a decrease of pressure inside the intestines, thus reducing the pain and bloating of IBS.3 

 

Butyrate can also ease constipation by helping the bowel muscles contract and retract properly.4 It also supports the health of the cells that line the intestine and reduces intestinal inflammation, easing the pain and digestive symptoms of IBS.5, 6, 7  Although these studies focus on IBS…the results can apply to other gastrointestinal complaints.

 

leaky gut

Defends Against Leaky Gut Syndrome

 

Studies indicate that butyrate may also help fix leaky gut, a condition that plagues so many people. Leaky gut syndrome is a condition in which your gut barrier is weakened or damaged. allowing toxins and other harmful substances to enter your bloodstream.

 

Leaky gut can lead to digestive health problems, weight gain, depression, anxiety, type 2 diabetes, and much more. Butyrate has been shown to repair and strengthen the intestinal lining, reducing your risk of leaky gut syndrome.8 Butyrate can also help prevent leaky gut by reducing gut inflammation, a major risk factor for leaky gut.

 

May Decrease Belly Fat

 

It might seem hard to believe, but your digestive tract plays a big role in your metabolism and your body’s ability to burn belly fat.

 

And here again, research suggests that butyrate might help reduce that stubborn abdominal fat. Indeed, butyrate should be included as part of your weight loss regimen. Studies show that butyrate may decrease body fat percentage, increase insulin sensitivity, and boost metabolism to burn body fat.9

 

All of this, of course, can lead to weight loss.

 

Other Health Benefits of Viscera-3™

 

Research also indicates that the butyrate in Viscera-3:

 

  • Supports the immune system10
  • Has anti-inflammatory properties11
  • Soothes anxiety12
  • Reduces the risk of colon cancer13
  • And much more.

 

Natural Ingredients in Viscera-3

 

The main gut-healing ingredient in Viscera-3™ is TRIButyrate, a patented form of Tributyrin clinically proven to transport butyrate to your lower colon, where it’s needed to do its job. (Tributyrin is a triglyceride that the body converts into butyrate.14) But to create the ultimate gut health supplement, we included four other natural ingredients clinically proven to support the digestive system and provide many other health benefits. 

 

Viscera-3™ contains:

 

Magnesium

 

Magnesium is an essential mineral involved in more than 300 biochemical processes in the body including:15, 16, 17

 

  • Protein synthesis
  • Blood glucose control
  • Nerve and muscle function
  • Blood pressure regulation
  • Energy production
  • And more

 

And magnesium is especially important to your gut health because without magnesium your body can’t perform the mechanics of digestion or physically move food through the body. Magnesium is also crucial to make stomach acid and to make digestive enzymes and to repair and protect your digestive organs, including your esophagus, stomach, intestines, pancreas, and even your colon.18

 

To help soothe digestive issues and support overall health, Viscera-3™ contains TWO types of magnesium!

Chromium

 

Chromium is another mineral essential for gut health and bodily function. It has been clinically proven to have positive effects on your lower intestine and fat in and around your gut, and particularly for its ability to reduce the risk of obesity, improve weight loss, burn belly fat and therefore reduce gut size…all while reducing cravings for fat and carbs. 

 

One of the reasons for this effect is that chromium has been found to be highly effective at balancing blood sugar and insulin levels. A double-blind study done by the USDA found that when individuals being treated for type 2 diabetes were given chromium supplements, insulin and cholesterol levels decreased significantly. And this was without making any changes to their diet!19  

 

Chromium is also known to improve insulin function,20 the hormone critical to the metabolism and storage of carbs and fat throughout the body and especially in your gut.21 

Pomegranate Fruit Extract

Pomegranate fruit has only recently revealed its powerful anti-aging gut health secret to doctors from Switzerland. 

In a groundbreaking study, doctors found that when pomegranate extracts are digested by gut bacteria, it produces a compound that prolongs lifespan and improves exercise capacity.22 This compound is called Urolithin A, which research suggests may help old and worn-out cells in your body recycle themselves to create new youthful cells.23

So, pomegranate fruit extract may be a potent anti-aging supplement that can help put a youthful bounce in your step!

Grape Seed Extract

Lastly, grape seed extract supports your immune system, digestive health, and cognitive function. It may also provide other health benefits. 

For instance, grape seed extract or GSE has been found to help reduce blood pressure, particularly in those who are carrying excess weight.24, 25   

And just like the rest of the Viscera-3™ formulation…

GSE has been found to help support brain health as you age and to help keep your mind sharp and active. 

In one 12-week study in 111 healthy older adults, it was found that taking GSE daily improved attention, language, and skill proficiency, and memory function.26

Other studies have found that GSE may prevent memory loss, improve cognitive status and brain antioxidant levels all while reducing brain lesions and amyloid clusters.27

Viscera-3™: The Last and Only Slim Gut Health Supplement You’ll Ever Need!

As you’ve seen, the natural ingredients in Viscera-3™ may support digestive health, assist with weight loss, reverse the signs of aging, support the immune system, and reduce the risk of many diseases. 

Viscera-3™ has no known negative side effects, and there is no financial risk of trying it out. In fact, Viscera-3™ comes with a 100% money back guarantee. If you are not satisfied with this product for any reason, we will refund your money. No questions asked.

With a money back guarantee like this, you have nothing to lose except digestive health issues, belly fat, and risk of disease.

And you have a LOT to gain in a stronger immune system, reduced weight, slimmer belly, more youthful appearance…and more!

So, purchase Viscera-3™ today and you could be writing a glowing 5-star review like this one:

 

★★★★★

 

“Our whole family swears by Viscera-3™! We all suffer from various digestion issues and get sick way more than we should. This is exactly what we have been searching for. Truly a gift from God. 

 

Bless you Jonathan and the team for putting this together. Really is a lifesaver for our entire family. We all have more pep in our step these days. And family movie night is not nearly as stinky as it used to be!”

 

★★★★★

 

References

 

1- Bérdy J. Bioactive microbial metabolites [published correction appears in J Antibiot (Tokyo). 2005 Apr;58(4):C-1]. J Antibiot (Tokyo). 2005;58(1):1-26. doi:10.1038/ja.2005.1

 

2- National Institute of Health. Digestive Diseases Statistics for the United States. November 2014.

 

3- Zaleski A, Banaszkiewicz A, Walkowiak J. Butyric acid in irritable bowel syndrome. Przegląd Gastroenterologiczny. December 2013 8(6):350-353.

 

4- Zaleski A, Banaszkiewicz A, Walkowiak J. Butyric acid in irritable bowel syndrome. Przegląd Gastroenterologiczny. December 2013 8(6):350-353.

 

5- Bach Knudsen KE, Lærke HN, Hedemann MS, Nielsen TS, Ingerslev AK, Gundelund Nielsen DS, Theil PK, Purup S, Hald S, Schioldan AG, Marco ML, Gregersen S, Hermansen K. Impact of Diet-Modulated Butyrate Production on Intestinal Barrier Function and Inflammation. Nutrients. 2018; 10(10):1499.

 

6- De Preter V, Arijs I, Windey K, et al. Impaired butyrate oxidation in ulcerative colitis is due to decreased butyrate uptake and a defect in the oxidation pathway. Inflamm Bowel Dis. 2012;18(6):1127-1136. doi:10.1002/ibd.21894

 

7- Hallert C, Björck I, Nyman M, Pousette A, Grännö C, Svensson H. Increasing fecal butyrate in ulcerative colitis patients by diet: controlled pilot study. Inflamm Bowel Dis. 2003;9(2):116-121. doi:10.1097/00054725-200303000-00005.

 

8- Michielan A, D’Incà R. Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut. Mediators Inflamm. 2015;2015:628157. doi:10.1155/2015/628157

 

9-Lin Zhang, Chudan Liu, Qingyan Jiang, Yulong Yin, Butyrate in Energy Metabolism: There Is Still More to Learn, Trends in Endocrinology & Metabolism, Volume 32, Issue 3, 2021, Pages 159-169, ISSN 1043-2760, https://doi.org/10.1016/j.tem.2020.12.003. (https://www.sciencedirect.com/science/article/pii/S1043276020302526)

 

10- Kelly Cushing, David M Alvarado, Matthew A Ciorba. Butyrate and Mucosal Inflammation: New Scientific Evidence Supports Clinical Observation. Clin Transl Gastroenterol. 2015 Aug; 6(8): e108.

 

11- Zaleski, A, Banaszkiewicz A, and Walkowiak J. Butyric acid in irritable bowel syndrome. Prz Gastroenterol 8: 350-353, 2013.

 

12- Rao AV, Bested AC, Beaulne TM, Katzman MA, Iorio C, Berardi JM, Logan AC. A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome. Gut Pathog. 2009 Mar 19;1(1):6. doi: 10.1186/1757-4749-1-6. PMID: 19338686; PMCID: PMC2664325.

 

13- Segain J, de la Blétière DR, Bourreille A, et alButyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn’s diseaseGut 2000;47:397-403.

 

14- National Center for Biotechnology Information (2020). PubChem Compound Summary for CID 6050, Tributyrin. Retrieved September 9, 2020 from

 

15- Institute of Medicine (IOM). Food and Nutrition Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluorideexternal link disclaimer. Washington, DC: National Academy Press, 1997.

 

16- Rude RK. Magnesium. In: Coates PM, Betz JM, Blackman MR, Cragg GM, Levine M, Moss J, White JD, eds. Encyclopedia of Dietary Supplements. 2nd ed. New York, NY: Informa Healthcare; 2010:527-37.

 

17- Rude RK. Magnesium. In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR, eds. Modern Nutrition in Health and Disease. 11th ed. Baltimore, Mass: Lippincott Williams & Wilkins; 2012:159-75.

 

18- 50- Ismail, A. A., & Ismail, N. A. (2016). Magnesium: A Mineral Essential for Health Yet Generally Underestimated or Even Ignored. Journal of Nutrition & Food Sciences, 6(4). doi:10.4172/2155-9600.1000523

 

19- Anderson RA1, Cheng N, Bryden NA. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes. 1997 Nov;46(11):1786-91.

 

20- Mertz W. Interaction of chromium with insulin: a progress report. Nutr Rev 1998;56:174-7.

 

21- Porte Jr. D, Sherwin RS, Baron A (editors). Ellengerg & Rifkin’s Diabetes Mellitus, 6th Edition. McGraw-Hill, New York, 2003.

 

22- Ryu D, Mouchiroud L, Andreux PA, Katsyuba E. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat Med. 2016 Aug;22(8):879-88. doi: 10.1038/nm.4132. Epub 2016 Jul 11.

 

23- Tan S, Yu CY, Sim ZW, Low ZS, Lee B, See F, Min N, Gautam A, Chu JJH, Ng KW, Wong E. Pomegranate activates TFEB to promote autophagy-lysosomal fitness and mitophagy. Sci Rep. 2019 Jan 24;9(1):727. doi: 10.1038/s41598-018-37400-1. PMID: 30679718; PMCID: PMC6346015.

 

24- Haili Zhang, MM,a Shuang Liu, MM,b Lan Li, BD,b Shisong Liu, BD. The impact of grape seed extract treatment on blood pressure changes A meta-analysis of 16 randomized controlled trials. Medicine (Baltimore). 2016 Aug; 95(33): e4247.

 

25- Park E, Edirisinghe I, Choy YY, Waterhouse A, Burton-Freeman B. Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial. Br J Nutr. 2016 Jan 28;115(2):226-38.

 

26- Calapai G, Bonina F, Bonina A. A Randomized, Double-Blinded, Clinical Trial on Effects of a Vitis vinifera Extract on Cognitive Function in Healthy Older Adults. Front Pharmacol. 2017 Oct 31;8:776.

 

27- Sarkaki A, Rafieirad M, Hossini SE. Improvement in Memory and Brain Long-term Potentiation Deficits Due to Permanent Hypoperfusion/Ischemia by Grape Seed Extract in Rats. Iran J Basic Med Sci. 2013 Sep;16(9):1004-10.

the better movie

BETTER Movie

Founder of Wellness Engineering and NYTimes Bestselling author Jonathan Bailor shares how personal tragedy led him to dedicate his life to finding a better way to eat, think, and live that reverses the causes and symptoms of diabetes and obesity (Diabesity).

YouTube video

BETTER Movie 2021

Featuring expert interviews on-location at Harvard Medical School with Dr. David Ludwig, Dr. JoAnn Manson, Dr. Kirsten Davison, and Dr. John Ratey, along with intimate testimonials of everyday Americans, we see the pain and struggle of the old-fashioned and ineffective “calories in, calories out” model, expose the lies that led to it, and provide a proven, practical, and pleasurable alternative.

the better movie

BETTER Movie culminates in offering a proven path toward better living by introducing revolutionary methods to lower the body weight “Setpoint” through evidence-based solutions that everyone can use to optimize their current diet (ex. keto, vegan, paleo, kosher, etc.) to prevent and reverse many of today’s most common diseases.

BETTER Movie Cast and Heroes

Fifteen BETTER© movie Cast members flew in from different parts of the country and met with Jonathan Bailor in Seattle. They were of different ages, came from different backgrounds, and had different stories to tell. But they all had one common goal: a burning desire to share their pain and struggles — and ultimate triumphs — over losing weight so that YOU don’t have to suffer!

Like millions of other people, they had struggled for years trying to lose weight using the inefficient “calories in calories out” model of weight loss. It had left them heavier, sicker, and filled with shame. Until they learned a better way of eating, thinking, and living presented in Jonathan Bailor’s BETTER© documentary movie and endorsed by top doctors at Harvard Medical School, Johns Hopkins, the Cleveland Clinic, and the Mayo Clinic.